Episode 218 is the one you've all been waiting for! A complete guide and breakdown to thyroid and its interactions when exogenous growth hormone is added to the mix! We went into a MASSIVE amount of detail and I collected a fair amount of the literature we reference within it. I will post a few top ones below because I had over 50 references for this episode.
Monson, J.P., Weaver, J.U., Noonan, K. et al. (1994) Effect of growth hormone on serum thyroid hormone concentrations and desmopressin requirements in adults with hypopituitarism and central diabetes insipidus: a preliminary report. Endocrinology and Metabolism, 1, 51–55.
Pirazzoli, P., Cacciari, E., Mandini, M. et al. (1992) Growth and thyroid function in children treated with growth hormone. Journal of Pediatrics, 121, 210–213.
Portes, E.S., Oliveira, J.H., MacCagnan, P. et al. (2000) Changes in serum thyroid hormone levels and their mechanisms during long term growth hormone(GH) replacement therapy in GH deficient children. Clinical Endocrinology (Oxf), 53, 183–189.
Porretti, S., Giavoli, C., Ronchi, C. et al. (2002) Recombinant human Gh replacement therapy and thyroid function in a large group of adult GH-deficient patients: when does L-T(4) replace- ment become mandatory? Journal of Clinical Endocrinology and Metabolism, 87, 2042–2045.
Seminara, S., Stagi, S., Candura, L. et al. (2005) Changes of thyroid function during long term hGH therapy in GHD children. A possi- ble relationship with catch up growth? Hormone and Metabolic Research, 37, 751–756.
Jorgensen, J.O., Pedersen, S.B., Borglum, J. et al. (1994) Fuel metabolism, energy expenditure, and thyroid function in growth hormone treated obese women: a double blind placebo controlled study. Metabolism, 43, 872–877.
Ó 2011 Blackwell Publishing Ltd, Clinical Endocrinology, 74, 281–288
Wyatt, D.T., Gesundheit, N. & Sherman, B. (1998) Changes in thy- roid hormone levels during growth hormone therapy in initially euthyroid patients: lack of need for thyroid supplementation. Jour- nal of Clinical Endocrinology and Metabolism, 83, 3493–3497.
Agha, A., Walker, D., Perry, L. et al. (2007) Unmasking of central hypothyroidism following growth hormone replacement in adult hypopituitary patients. Clinical Endocrinology, 66, 72–77.
Losa, M., Scavini, M. & Gatti, E., et al. (2008) Long-term effects of growth hormone replacement therapy on thyroid function in adults with growth hormone deficiency. Thyroid, 19, 1249–1254.
Giavoli, C., Porretti, S., Ferrante, E. et al. (2003) Recombinant hGH replacement therapy and the hypothalamus-pituitary-thyroid axis in children with GH deficiency: when should we be concerned about the occurrence of central hypothyroidism? Clinical Endocri- nology, 59, 806–810.
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